Circadian variations in blood pressure, heart rate, and HR-BP Cross-Correlation Coefficient during progression of diabetes mellitus in rats
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Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n = 8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ±0.06; BBDR: 0.65 ± 0.03; P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.
Circadian rhythm , Blood pressure , Heart rate , Cross-correlation coefficient , Diabetes mellitus , Research Subject Categories::MEDICINE
Anigbogu C.N, [Et...al] (2011). Circadian variations in blood pressure, heart rate, and HR-BP Cross-Correlation Coefficient during progression of diabetes mellitus in rats. International Journal of Hypertension,1 – 8. .