Circadian variations in blood pressure, heart rate, and HR-BP Cross-Correlation Coefficient during progression of diabetes mellitus in rats

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dc.contributor.authorAnigbogu, C.N.
dc.contributor.authorWilliams, D.T.
dc.contributor.authorBrown, D.R.
dc.contributor.authorSilcox, D.L.
dc.contributor.authorSpeakman, O.R.
dc.contributor.authorBrown, L.C.
dc.contributor.authorKarounos, D.G.
dc.contributor.authorRandall, D.C.
dc.date.accessioned2019-10-04T13:16:23Z
dc.date.available2019-10-04T13:16:23Z
dc.date.issued2011
dc.descriptionStaff publicationsen_US
dc.description.abstractCircadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n = 8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ±0.06; BBDR: 0.65 ± 0.03; P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.en_US
dc.identifier.citationAnigbogu C.N, [Et...al] (2011). Circadian variations in blood pressure, heart rate, and HR-BP Cross-Correlation Coefficient during progression of diabetes mellitus in rats. International Journal of Hypertension,1 – 8. .en_US
dc.identifier.otherdoi:10.4061/2011/738689
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6248
dc.language.isoenen_US
dc.publisherSAGE-Hindawi Access to Researchen_US
dc.relation.ispartofseriesInternational Journal of Hypertension;
dc.subjectCircadian rhythmen_US
dc.subjectBlood pressureen_US
dc.subjectHeart rateen_US
dc.subjectCross-correlation coefficienten_US
dc.subjectDiabetes mellitusen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleCircadian variations in blood pressure, heart rate, and HR-BP Cross-Correlation Coefficient during progression of diabetes mellitus in ratsen_US
dc.typeArticleen_US
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