Modulatory effect of fibre-enriched cake on alloxan-induced diabetic toxicity in rat brain tissues.
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Date
2014
Authors
Ebuehi, O.A.T.
Erukainure, O.L.
Adeboyejo, F.O.
Muhammad Aliyu
Elemo, G.N.
Journal Title
Journal ISSN
Volume Title
Publisher
Toxicology Reports(Elsevier)
Abstract
Diabetes is a metabolic disorder characterized by hyperglycaemia and it is fast becoming a
scourge in sub-Saharan Africa. The nutritional properties of developed fibre-enriched cake
and its protective potential against diabetic induced neurotoxicity in rats were investigated.
Fibre-enriched cake was developed from selected fruits and analysed for its nutritional and
sensory attributes. Rats were induced with diabetes by a single intraperitoneal injection
of alloxan and treated with the formulated cake. After 14 days treatment, the rats were
sacrificed by cervical dislocation. Their brain tissues were accessed for reduced glutathione
(GSH), catalase, superoxide dismutase (SOD) activities, protein content and lipid peroxida tion as well as lipid profiles which cover for total cholesterol, triglycerides, HDL and LDL.
Induction of diabetes led to significant reduction (p < 0.05) of GSH, catalase, SOD activi ties and protein content. Feeding on the formulated cake led to their significant increase.
Decreased lipid peroxidation, total cholesterol, LDL and triglycerides, and increased con centration of HDL were also observed on feeding with the cake. These results indicate an
antioxidant protective potential of the fibre-enriched cake against diabetic-induced brain
toxicity. Thus, it can serve as an adjunct to dietary therapy for diabetes.
Description
Scholarly article
Keywords
Citation
Ochuko L. Erukainure, Osaretin A.T. Ebuehi, Folasade O. Adeboyejo, Muhammad Aliyu, Gloria N. Elemo (2014). Modulatory effect of fibre-enriched cake on alloxan-induced diabetic toxicity in rat brain tissues. Toxicology Reports(Elsevier), 1: 445-449.