COMPARATIVE ALKYLATING ACTIVITY OF AQUEOUS ROOT BARK EXTRACT OF SECURIDACA LONGEPEDUNCULATA (POLYGALACEAE) AND CHLORAMBUCIL USING THE NITROBENZYL PYRIDINE ASSAY

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dc.contributor.authorEbuehi, O.A.T.
dc.contributor.authorLAWAL, R.A
dc.contributor.authorODESANMI O.S
dc.contributor.authorNKEMEHULE, F
dc.contributor.authorLAWAL, S.K
dc.contributor.authorATANDA, J.F
dc.contributor.authorJIMOH, Y.O
dc.date.accessioned2024-05-08T12:11:05Z
dc.date.available2024-05-08T12:11:05Z
dc.date.issued2018
dc.descriptionScholarly article
dc.description.abstractSecuridacalongepedunculata (polygalaceae) is a shrub found growing in Nigeria and some parts of Africa. Several studies support its reported cytotoxicity to cancer cells. However, the mechanism by which it cures cancer has not been fully elucidated. The aim of the study is to compare the alkylating activity of aqueous root-bark extract of S. longepedunculata (polygalaceae) and chlorambucil. The nitrobenzyl pyridine assay was used to determine the alkylating activity of S. longepunculata. The results indicate a time- and concentration-dependent increase in alkylating activity of S. longepedunculata. Securidacalongepedunculata shows cytotoxicity through its alkylating activity which is comparable to chlorambucil.
dc.identifier.citationLAWAL, R.A, IODESANMI O.S, NKEMEHULE, F. (2018). COMPARATIVE ALKYLATING ACTIVITY OF AQUEOUS ROOT BARK EXTRACT OF SECURIDACA LONGEPEDUNCULATA (POLYGALACEAE) AND CHLORAMBUCIL USING THE NITROBENZYL PYRIDINE ASSAY. Journal Industrial Research and Technology 7(1):53-57
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/12867
dc.language.isoen
dc.publisherJournal Industrial Research and Technology
dc.titleCOMPARATIVE ALKYLATING ACTIVITY OF AQUEOUS ROOT BARK EXTRACT OF SECURIDACA LONGEPEDUNCULATA (POLYGALACEAE) AND CHLORAMBUCIL USING THE NITROBENZYL PYRIDINE ASSAY
dc.typeArticle
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