Human immunodeficiency virus status in malnourished children seen at Lagos

Simple item page
dc.contributor.authorTemiye, E.O
dc.contributor.authorAdeniyi, O.F
dc.contributor.authorFajolu, I.B
dc.contributor.authorOgbenna, A.A
dc.contributor.authorLadapo, T.A
dc.contributor.authorEsezobor, C.I
dc.contributor.authorAkinsulie, A.O
dc.contributor.authorMabogunje, C.A
dc.date.accessioned2022-01-31T12:22:04Z
dc.date.available2022-01-31T12:22:04Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractHuman immunodeficiency virus and protein energy malnutrition are still prevalent in Nigeria and the occurrence of the two conditions together confers a poor prognosis. The aim of this study was to determine the current categories of malnutrition amongst under-5 children in Lagos, document their HIV status and determine any peculiarities in the clinical features, haematological and some biochemical profile in these children. Methods The study was a cross-sectional study conducted at the Paediatric departments of the Lagos University Teaching Hospital and the Massey Street Children’s Hospital, both in Lagos, over a 6-month period. All the subjects had anthropometry, HIV testing, full blood count and serum proteins done. The factors associated with HIV status were determined with the logistic regression analysis. Results Two hundred and fourteen (214) malnourished children 5 years, including 25 (11.7%) with HIV were recruited in the study. Among the study participants, 150 (70.1%) and 54 (29.9%) had moderate and severe malnutrition, respectively. Fever, cough and diarrhea were the most common symptoms in the study participants. The haematological indices were compa- rable in the two groups, the serum globulin levels though higher in the HIV infected group was not statistically significantly different from the non-infected group.(p = 0.66). None of the factors explored on multivariate analysis was able to predict the occurrence of the infec- tion in this cohort. Conclusion Malnourished children remain a high risk group for HIV infection and the prevalence of the infection obtained in this group of children is still unacceptably high. Discriminatory features between malnutrition and HIV remains difficult. The presence of hyperglobulinaemia on lab- oratory analysis in a malnourished child may heighten the suspicion of possible underlying associated HIV infection. Screening of malnourished children for HIV infection and further longitudinal studies on malnourished children with HIV is advocateden_US
dc.description.sponsorshipThis study received some funding from the Central Research Committee of University of Lagos, Lagos, Nigeria; Grant number: CRC.NO. 2015/09.en_US
dc.identifier.citationTemiye, E.O., Adeniyi, O.F., Fajolu, I.B., Ogbenna, A.A., Ladapo, T.A., Esezobor, C.I., et al. (2018) Human immunodeficiency virus status in malnourished children seen at Lagos. PLoS ONE, 13(10): e0200435. https://doi.org/10.1371/journal.pone.0200435en_US
dc.identifier.other10.1371/journal.pone.0200435
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10868
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectHuman immunodeficiency virusen_US
dc.subjectMalnutritionen_US
dc.subjectHIV statusen_US
dc.subjectChildrenen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleHuman immunodeficiency virus status in malnourished children seen at Lagosen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Human immunodeficiency virus status in malnourished children seen at Lagos.pdf
Size:
560.7 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Haematology and Blood Transfusion- Scholarly Publications