Risk of congenital cardiovascular anomalies in patients with non-syndromic orofacial cleft: A preliminary case-control study.
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Date
2020-11
Authors
James, O.
Erinoso, O.A.
Adamson, O.O.
Sokunbi, O.J.
Agbogidi, F.O.
Adekunle, A.A.
Ogunlewe, A.O.
Ekure, E.N.
Adeyemo, W.L.
Ladeinde, A.L.
Journal Title
Journal ISSN
Volume Title
Publisher
Medical and Dental Consultants' Association of Nigeria.
Abstract
Background: Orofacial clefts (OCs) are one of the most common craniofacial
anomalies and are reported to be associated with congenital cardiovascular
anomalies (CCAs). However, there is paucity of data in African populations on the
risk of CCAs in OC patients compared to the general population. Aims: This study
aims to determine the odds of congenital cardiovascular anomalies in patients with
OC compared to the general population. Subjects and Methods: A case‑control
study design was used. Case subjects were non‑syndromic OC subjects, while
controls were non‑syndromic subjects without OC. All subjects were thoroughly
assessed by a pediatric cardiologist for CCAs; and grouped by OC phenotypic
type (cleft lip and/or alveolus, cleft lip and palate, cleft palate only and Tessier
cleft). Statistical analysis was done using STATA version 14 (College Station,
Texas), and significance was placed at P value ≤0.05. Results: A total of 120
subjects (60 cases and 60 controls) were enrolled in the study. In total, 23.3% of the
subjects had CCAs. Among the case group, 40% had CCAs compared to 6.7% in
the control group. Patent foramen ovale (18.3%) and atrial septal defects (10.0%)
were the most common type of CCAs in cases, respectively. Further, cases had
significantly higher odds of CCAs compared to controls (OR: 9.3; CI: 2.8, 39.4).
Conclusions: Our finding reveals that the odds of CCAs are significantly higher in
patients with OC than the general population. Future studies could assess the effect
of CCAs on surgical outcome.
Description
Scholarly articles
Keywords
Congenital cardiovascular anomalies , orofacial cleft , Craniofacial anomalies , Research Subject Categories::MEDICINE , Patients
Citation
James O, Erinoso OA, Adamson OO, Sokunbi OJ, Agbogidi FO, Adekunle AA, Ogunlewe AO, Ekure EN, Adeyemo WL, Ladeinde AL, Ogunlewe MO. Risk of congenital cardiovascular anomalies in patients with non-syndromic orofacial cleft: A preliminary case-control study. Niger J Clin Pract. 2020 Nov;23(11):1561-1565. doi: 10.4103/njcp.njcp_176_20. PMID: 33221782.