The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women (Review)
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Date
2009
Authors
Oduyebo, O.O.
Anorlu, R.I.
Ogunsola, F.T.
Journal Title
Journal ISSN
Volume Title
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Abstract
Background
Bacterial vaginosis (BV) is a very common cause of vaginitis that has been associated with a high incidence of obstetric and gynaecologic complications and increased risk of HIV-1 transmission. This has led to renewed research interest in its treatment.
Objectives
To assess the effects of antimicrobial agents on BV in non-pregnant women. Search methods
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE, EMBASE, LILACS, and African Healthline (December 2007); and proceedings of relevant international conferences (from 1981 to date).
Selection criteria
Randomised controlled trials comparing any two or more antimicrobial agents, or antimicrobial agents with placebo or no treatment, in women with clinical or Gram-stain criteria of BV.
Data collection and analysis
Two authors independently assessed trial quality and extracted data from the original publications while the third author cross checked the data.
Main results
Twenty-four trials involving 4422 participants were reviewed. Most examined symptomatic women only. Only seven trials analysed results by intention to treat; we re-analysed the remainder.
Compared with placebo, clindamycin showed a lower rate of treatment failure (relative risk (RR) 0.25, 95% confidence interval (CI) 0.16 to 0.37). Clindamycin and metronidazole showed identical rates of treatment failure, irrespective of regimen type, at two and fourweek follow up (RR 1.01, 95% CI 0.69 to 1.46; RR 0.91, 95% CI 0.70 to 1.18, respectively). Clindamycin tended to cause a lower rate of adverse events (RR 0.75, 95% CI 0.56 to 1.02); metallic taste, and nausea and vomiting were more common in the metronidazole
Description
Staff publications
Keywords
Bacterial vaginosis , vaginitis , Obstetric and gynaecologic complications , HIV , Treatment , Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Citation
Oduyebo, O.O, Anorlu, R.I. and Ogunsola, F.T. (2009). The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database of Systematic Reviews, Issue 3. DOI: 10.1002/14651858.CD006055.pub2.
URI
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https://ir.unilag.edu.ng/handle/123456789/7244
https://ir.unilag.edu.ng/handle/123456789/7244