The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women (Review)

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dc.contributor.authorOduyebo, O.O.
dc.contributor.authorAnorlu, R.I.
dc.contributor.authorOgunsola, F.T.
dc.date.accessioned2020-01-06T11:34:56Z
dc.date.available2020-01-06T11:34:56Z
dc.date.issued2009
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground Bacterial vaginosis (BV) is a very common cause of vaginitis that has been associated with a high incidence of obstetric and gynaecologic complications and increased risk of HIV-1 transmission. This has led to renewed research interest in its treatment. Objectives To assess the effects of antimicrobial agents on BV in non-pregnant women. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE, EMBASE, LILACS, and African Healthline (December 2007); and proceedings of relevant international conferences (from 1981 to date). Selection criteria Randomised controlled trials comparing any two or more antimicrobial agents, or antimicrobial agents with placebo or no treatment, in women with clinical or Gram-stain criteria of BV. Data collection and analysis Two authors independently assessed trial quality and extracted data from the original publications while the third author cross checked the data. Main results Twenty-four trials involving 4422 participants were reviewed. Most examined symptomatic women only. Only seven trials analysed results by intention to treat; we re-analysed the remainder. Compared with placebo, clindamycin showed a lower rate of treatment failure (relative risk (RR) 0.25, 95% confidence interval (CI) 0.16 to 0.37). Clindamycin and metronidazole showed identical rates of treatment failure, irrespective of regimen type, at two and fourweek follow up (RR 1.01, 95% CI 0.69 to 1.46; RR 0.91, 95% CI 0.70 to 1.18, respectively). Clindamycin tended to cause a lower rate of adverse events (RR 0.75, 95% CI 0.56 to 1.02); metallic taste, and nausea and vomiting were more common in the metronidazoleen_US
dc.identifier.citationOduyebo, O.O, Anorlu, R.I. and Ogunsola, F.T. (2009). The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database of Systematic Reviews, Issue 3. DOI: 10.1002/14651858.CD006055.pub2.en_US
dc.identifier.otherDOI: 10.1002/14651858.CD006055.pub2.
dc.identifier.urihttps://www.google.com/search?q=The+effects+of+antimicrobial+therapy+on+bacterial+vaginosis+in+non-pregnant+women+(Review)&oq=The+effects+of+antimicrobial+therapy+on+bacterial+vaginosis+in+non-pregnant+women+(Review)&aqs=chrome..69i57.499j0j9&sourceid=chrome&ie=UTF-8
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7244
dc.language.isoenen_US
dc.relation.ispartofseriesCochrane Database of Systematic Reviews;(3)
dc.subjectBacterial vaginosisen_US
dc.subjectvaginitisen_US
dc.subjectObstetric and gynaecologic complicationsen_US
dc.subjectHIVen_US
dc.subjectTreatmenten_US
dc.subjectResearch Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiologyen_US
dc.titleThe effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women (Review)en_US
dc.typeArticleen_US
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