Department of Obstetrics and Gynaecology

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Browsing Department of Obstetrics and Gynaecology by Author "Abudu, O.O."

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    Open Access
    Diabetes Mellitus
    (Textbook of Obstetrics and Gynaecology for Medical students Heinemann Educational Books(Nigeria) Plc, 2006) Abudu, O.O.; Afolabi, B.B.
    Diabetes mellitus is the metabolic disease that results from lack of insulin. The World Health Organisation Expert Committee on diabetes mellitus defined the disease in terms of blood glucose levels. If the random blood glucose is equal to or greater than 1l.0 mmol/l in a (non-pregnant) patient with polyuria, polydipsia, weight loss and occasional glycosuria, that patient has diabetes.
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    Open Access
    Evaluation of haematological parameters in pregnant Nigerian women with sickle cell disease
    (Nigerian Quarterly Journal of Hospital Medicine, 2014) Afolabi, B.B.; Akanmu, A.S.; Oluwole, A.A.; Kehinde, M.O.; Abudu, O.O.
    Full texts attached
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    Open Access
    Fasting plasma glucose levels in normal pregnant Nigerians
    (J Obstet Gynaecol, 2003) Afolabi, B.B.; Abudu, O.O.; Oyeyinka, O.
    Summary A study was undertaken to determine a reference value for fasting plasma glucose in a group of apparently normal pregnant Nigerian women. Three hundred and twenty women were tested; 260 pregnant and 60 non-pregnant. There were 60, 100 and 100 subjects in the first, second and third trimesters, respectively. Fasting plasma glucose was measured in each of the women using the glucose oxidase method. The mean fasting plasma glucose level was 4.64+0.79 mmol/l in the control group and 3.72+0.58, 3.78+0.81 and 3.81+0.85 mmol/l in the first, second and third trimesters of pregnancy, respectively. Mean fasting plasma glu￾cose+ 2 standard deviations (SD) of all the pregnant women was 5.3 mmol/l, which is much lower than the World Health Organisa￾tion value for the diagnosis of diabetes mellitus.
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    Open Access
    Hydramnios
    (Textbook of Obstetrics and Gynaecology for Medical students Heinemann Educational Books(Nigeria) Plc, 2006) Abudu, O.O.; Afolabi, B.B.
    Hydramnios {or polyhydramnios) means excess of amniotic fluid ( or liquor amnii). The average volume of amniotic fluid at term is about 800ml ( range: 400-1500ml). Any volume above the upper limit of normal is decribed as excessive. Clinically, volumes above 2000ml are palpably obvious as cases of polyhyramnios.
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    Open Access
    Low birth weight
    (Textbook of Obstetrics and Gynaecology for Medical students, Heinemann Educational Books(Nigeria) Plc, 2006) Abudu, O.O.; Afolabi, B.B.
    World Health Organization (WHO) currently recommends that any baby that weighs less than 2.5kg at birth is a low birth weight (LBW) baby. definition includes babies born too early (before 37 completed weeks of gestation, i.e. preterm babies), babies with intrauterine growth restriction, and babies that are both preterm and growth restricted. However, babies who are born at term and above 2.5kg but have lower birth weights than appropriate for gestational age, are not included in this definition even though they may be susceptible to similar problems as those below 2.5kg.
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    Open Access
    Pregnancy induced hypertension, pre-eclampsia and chronic hypertension
    (Textbook of Obstetrics and Gynaecology for Medical students Heinemann Educational Books(Nigeria) Plc, 2006) Abudu, O.O.; Afolabi, B.B.
    Pregnancy Induced Hypertension (PIH) PIH is the development of hypertension in the second half of pregnancy on two or more occasions, about 4 hours apart, in a woman who has previously been normotensive, and in whom blood pressure (BP) returns to normal within 6 weeks of delivery. PIH without proteinuria is a relatively benign condition and usually occurs in the third trimester, during labour or the puerperium. Perinatal mortality is usually not increased in this condition and it is thus important to distinguish between it and PE.
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    Open Access
    A study of urinary prostacyclin products and some haematological parameters in pregnant women with sickle cell anaemia
    (Journal of Clinical Sciences, 2013) Akanmu, A.S.; Afolabi, B.B.; Taiwo-Osunubi, P.A.; Abudu, O.O.
    Objective: Normal gestation is associated with an increased plasma volume (PV) and vasodilation which plasma prostacyclin (PGI2) may account for. This study measured PGI2 levels in pregnant haemoglobin (Hb) SS patients as they have been reported to lack PV expansion. Methods: Urinary prostacyclin (UP) concentration and full blood count parameters were determined in pregnant Hb AA and Hb SS women, with non-pregnant controls. Results: Thirty-three Hb AA (19 non-pregnant and 14 pregnant) and 25 Hb SS (18 non-pregnant and 7 pregnant) were studied. UP did not rise in pregnant Hb SS women compared to non-pregnant (Geometric mean (GM) 614 ± 2.4 vs 248 ± 3.8, p=0.063), despite a very significant rise in Hb AA pregnancy (GM 1406 ± 2.1 vs 260 ± 2.9 pg/ml, p<0.0001). Conclusion: There is a lack of significant rise in plasma prostacyclin levels during pregnancy in Hb SS women, which could account for their reported lack of plasma volume expansion
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    Open Access
    A study of urinary prostacyclin products and some haematological parameters in pregnant women with sickle cell anaemia
    (Journal of Clinical Sciences, 2013) Akanmu, A.S.; Afolabi, B.B.; Taiwo-Osunubi, P.A.; Abudu, O.O.
    Objective: Normal gestation is associated with an increased plasma volume (PV) and vasodilation which plasma prostacyclin (PGI2) may account for. This study measured PGI2 levels in pregnant haemoglobin (Hb) SS patients as they have been reported to lack PV expansion. Methods: Urinary prostacyclin (UP) concentration and full blood count parameters were determined in pregnant Hb AA and Hb SS women, with non-pregnant controls. Results: Thirty-three Hb AA (19 non-pregnant and 14 pregnant) and 25 Hb SS (18 non-pregnant and 7 pregnant) were studied. UP did not rise in pregnant Hb SS women compared to non-pregnant (Geometric mean (GM) 614 ± 2.4 vs 248 ± 3.8, p=0.063), despite a very significant rise in Hb AA pregnancy (GM 1406 ± 2.1 vs 260 ± 2.9 pg/ml, p<0.0001). Conclusion: There is a lack of significant rise in plasma prostacyclin levels during pregnancy in Hb SS women, which could account for their reported lack of plasma volume expansion.
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    Open Access
    Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder
    (J Renin Angiotensin Aldosterone Syst, 2016-07) Afolabi, B.B.; Oladipo, O.O.; Akanmu, A.S.; Abudu, O.O.; Sofola, O.A.; Broughton Pipkin, F.
    Sickle cell disease (haemoglobin SS (HbSS)) mainly affects those of West African origin and is associated with hypervolaemia. Plasma volume rises by up to 50% in normal pregnancy but was previously found to be paradoxically contracted in late sickle cell pregnancy. The renin-angiotensin-aldosterone system is activated very early in human pregnancy to support the plasma volume expansion. We hypothesised that activation of the renin-angiotensin-aldosterone system would be blunted in pregnant women with sickle cell disease.