Pharmaceutical Chemistry- Scholarly Publications

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Browsing Pharmaceutical Chemistry- Scholarly Publications by Author "Adegoke A.O."

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    Open Access
    Evaluation of Antioxidant Activity of Tetracarpidium conophorum (M¨ull. Arg) Hutch & Dalziel Leaves
    (Oxidative Medicine and Cellular Longevity, 2011) Amaeze O.U.; Ayoola G.A.; Sofidiya M.O.; Adepoju-Bello A.A.; Adegoke A.O.; Coker H.A.B.
    This study evaluated the antioxidant activity as well as bioflavonoid content of the methanol and ethanol-water extracts of the freshand dried leaves of Tetracarpidium conophorum. Antioxidant activity was determined by spectrophotometricmethods using DPPH.free radical, nitric oxide radical inhibition and ferric reducing antioxidant power assays. In addition, total phenolics, flavonoids.and proanthocyanidin content were also determined. The ethanol: water extract of the dried leaves had the highest antioxidant activity with a 50% inhibition of DPPH at a concentration of 0.017 mg/mL compared to the standards, Vitamin C and Vitamin E with inhibition of 0.019 and 0.011 mg/mL, respectively. This extract also showed nitric oxide radical inhibition activity comparable .to that of rutin, 54.45% and 55.03% for extract and rutin, respectively, at 0.1 mg/mL. Ferric reducing power was also comparable tothat of ascorbic acid (281 and 287 μMFe (11)/g, resp.) at a concentration of 1 mg/mL. The methanol extract of both the dried andthe fresh leaves had higher phenolic, flavonoids and proanthocyanidin content than the ethanol : water extract. The study reveals that T. conophorum can be an interesting source of antioxidants with their potential use in different fields namely food, cosmetics.and pharmaceuticals.
  • Item
    Open Access
    Investigation of the antioxidant properties of Chrysophyllum albidum leaves
    (Nigerian Journal of Health and Biomedical Sciences, 2011) Adeshina Y.O.; Ayoola G.A.; Adegoke A.O.; Adepoju-Bello, A.A.
    Chrysophyllum albidum G Don, Sapotaceae is an indigenous plant in traditional medicine of West africa used for fever, stomach ache, diarrhea and wound healing. The present study was undertaken.to evaluate the phytochemical and antioxidant properties of Chrysophyllum albidum (leaves). The.plant extract was tested for DPPH (1, 1-diphenyl-2-picryl hyrazyl) radical scavenging activity, iron.chelating activity, total phenolic, total flavonoid, proanthocyanidin and total iron content. The leaves tested positive to alkaloids, flavonoids, glycosides, saponins, iron, fixed oils and reducing sugars but.tested negative for the presence of volatile oils, anthracene glycosides, deoxy pentose and keto sugars. The IC50 values were {20 μg/m!, 23 μg/ml for DPPH activity in the order {Vitamin C, Extract} while the IC50 values for the iron chelating activity were {16 μg/ml, indeterminate} in the order of {NaEDTA, Extract}. The total phenolic content, total flavonoid content, and proanthocyanidin contents are 1058 mg, 669 mg, and 353.7 mg; as gallic acid, rutin and catechin equivalents per 100 qrams of the leaves respectively. The total iron content was 2.82 mg/g of the leaves extract. The results obtained in the present study indicate that extracts of C. albidum leaves are potential sources of natural antioxidants.