Department of Pharmaceutical Chemistry

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Browsing Department of Pharmaceutical Chemistry by Author "Adepoju-Bello, A.A."

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    Open Access
    Impact of Yoyo bitters® on the Pharmacokinetic Profile of Ciprofloxacin in Healthy Nigerian Volunteers
    (2018-10-23) Martins, O.C.; Akinleye, M.O.; Ukpo, G.E.; Adepoju-Bello, A.A.; Odediran, B.B.; Onun, E.O.; Makinde, P.A.
    Ciprofloxacin and Yoyo bitters® (a liquid herbal oral preparation) are readily and widely available as prescription drug and herbal medicine, respectively in Nigeria. They are taken separately or concomitantly. The high metal content of Yoyo bitters poses to be a potential problem for the bioavailability of fluoroquinolones. Thus, this study was carried out to investigate the possible drug-herb interaction between Ciprofloxacin tablet and Yoyo bitters when co-administered. Pharmacokinetics of oral single dose ciprofloxacin (500 mg) tablet was evaluated in 30 healthy volunteers. The study design was an open, single dose randomized two-way comparative crossover treatment groups. Each group either took ciprofloxacin (500 mg) tablet with 200 mL of water or ciprofloxacin with 30 mL of yoyo bitters. A wash out period of two weeks was observed, and the treatment groups were interchanged. Blood samples were collected and analyzed for ciprofloxacin in plasma using a modified High-Performance Liquid Chromatographic (HPLC) method with UV detector at 278nm. Non-compartmental analysis was employed for pharmacokinetic parameters estimation. Results indicated that Yoyo bitters altered the Pharmacokinetics of ciprofloxacin (Cmax, AUC, Vd, Tmax, t1/2, Kel and Kab) when administered concomitantly, although not statistically significant (p>0.05). Therefore, for the desired therapeutic effect of ciprofloxacin to be optimally achieved, concomitant administration with Yoyo bitters or any herbal preparation should be staggered.
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    Open Access
    Investigation of the antioxidant properties of Chrysophyllum albidum leaves
    (Nigerian Journal of Health and Biomedical Sciences, 2011) Adeshina Y.O.; Ayoola G.A.; Adegoke A.O.; Adepoju-Bello, A.A.
    Chrysophyllum albidum G Don, Sapotaceae is an indigenous plant in traditional medicine of West africa used for fever, stomach ache, diarrhea and wound healing. The present study was undertaken.to evaluate the phytochemical and antioxidant properties of Chrysophyllum albidum (leaves). The.plant extract was tested for DPPH (1, 1-diphenyl-2-picryl hyrazyl) radical scavenging activity, iron.chelating activity, total phenolic, total flavonoid, proanthocyanidin and total iron content. The leaves tested positive to alkaloids, flavonoids, glycosides, saponins, iron, fixed oils and reducing sugars but.tested negative for the presence of volatile oils, anthracene glycosides, deoxy pentose and keto sugars. The IC50 values were {20 μg/m!, 23 μg/ml for DPPH activity in the order {Vitamin C, Extract} while the IC50 values for the iron chelating activity were {16 μg/ml, indeterminate} in the order of {NaEDTA, Extract}. The total phenolic content, total flavonoid content, and proanthocyanidin contents are 1058 mg, 669 mg, and 353.7 mg; as gallic acid, rutin and catechin equivalents per 100 qrams of the leaves respectively. The total iron content was 2.82 mg/g of the leaves extract. The results obtained in the present study indicate that extracts of C. albidum leaves are potential sources of natural antioxidants.