Department of Pharmaceutical Chemistry

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Browsing Department of Pharmaceutical Chemistry by Author "Adepoju-Bello A."

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    Open Access
    Aflatoxin Contamination of Arachis hypogaea (Groundnuts) in Lagos Area of Nigeria
    (Bulletin of Environmental Contamination and Toxicology, 2003) Thomas A.E.; Coker H.A.B.; Odukoya O.A.; Isamah G.K.; Adepoju-Bello A.
    Human populations are exposed to aflatoxins as a result of the consumption of commodities particularly grams and nuts) that have been directly contaminated by the aflatoxin producing strains of Aspergillus flavus and Aspergilus parasiticus during growth, harvest or storage (Busby and Wogan 1984). The occurrence and magnitude of aflatoxins contamination varies also with geographical and seasonal factors. Crops in tropical and subtropical areas are more susceptible to contamination than those in temperate regions, since optimal conditions for toxin formation are prevalent in areas with high humidity and temperature (Diener and Davis 1969). Grains and food stuffs capable of being contaminated with aflatoxins have been reported by Busby and Wogan and the level of contamination can vary from less than lppb to over 12ppb. In Nigeria, grains like groundnuts (Arachis hypogaea) have become a staple food among the populace and there is need to consider the sporadic nature of the infestation of these nuts. In this study, the level of aflatoxin contamination of groundnuts (roasted, steamed and raw), was evaluated, using ultraviolet-visible spectrophotometric and high performance liquid chromatographic methods.
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    Open Access
    Identification of Phenolic Acids and Free Phenols of the Stem Barks Parkia biglobosa (JACQ.) Mimosaceae : Comparative study of the activity of the total and hydroalcoholic extracts with that of the Gentamicin against pathogenic bacteria
    (West Afr. J. Pharrn., 2001) Millogo H.; Guissou I.P.; Idika N.; Adepoju-Bello A.; Coker H.A.B.; Agomo P.U.
    The chemical screening of the stem bark of Parkia biglobosa has shown that they are rich in polyphenolic compounds. The extraction of these compounds with ethanol was followed by the identification of phenolic acids and free phenols using paper chromatography. The aqueous and ethanolic extracts were proven active against a number of pathogenic bacteria. The gentamicin was found far more active than the etlzanolic and the aqueous extracts against the tested pathogenic bacteria.
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    Open Access
    A Screening for Selected Analgesic Pharmaceuticals in Water from a Hospital Environment in Ogun State, Nigeria Using Spe-LC
    (J. Phann. Sci. & Pharm. Pract., 2014) Olaitan O.J.; Afonja B.; Anyakora C.; Adepoju-Bello A.
    Commonly used prescription and over-the-counter pharmaceuticals are possibly present in environmental water samples at minute concentrations. In this research, a combined solid-phase extraction isolation and high-performance liquid chromatography (UV Detector) analytical procedure were employed for determination of the presence and concentration of human-health analgesic pharmaceuticals (Paracetamol, Diclofenac Sodium and Ibuprofen) in tap and well water samples collected from the well and tap of two hospitals in Abeokuta, Ogun State, Nigeria. The calibration curves obtained were all linear with a correlation coefficient ranging from 0.9882-0.9999. The pharmaceuticals were all found in the water samples. The average concentrations of these pharmaceuticals are 0.242μg/L, 0.103μg/L and 3.402μg/L for Paracetamol, Diclofenac Sodium and Ibuprofen respectively. The presence of these drugs in water can constitute a significant environmental problem that should be addressed by the monitoring of these drugs and by implementation of methodologies that contribute to their decrease/elimination from water and waste water generally.