Department of Pharmaceutical Chemistry

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Browsing Department of Pharmaceutical Chemistry by Author "Adesegun, S."

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    Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition
    (Natural Product Research Formerly Natural Product Letters, 2019-11-08) Alaribe, S.C.; Esposito, T.; Sansone, F.; Adesegun, S.; Pagano, I.; Piccinelli, A.L.; Celano, R.; Cuesta Rubio, O.; Coker, H.A.; Nabavi, S.M.; Rastrelli, L.; Picerno, P.
    Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against a-amylase and a-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.