Anatomic and Molecular Pathology- Scholarly Publications

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Browsing Anatomic and Molecular Pathology- Scholarly Publications by Author "Abudu, EK"

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    Open Access
    Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: A histopathological review
    (World Journal of Gastroenterology, 2008) Abdulkareem, FB; Abudu, EK; Awolola, NA; Elesha, SO; Rotimi, O; Akinde, OR; Atoyebi, OA; Adesanya, AA; Daramola, AO; Banjo, AAF; Anunobi, CC
    AIM: To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria. METHODS: This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos & Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study. RESULTS: There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages Ⅱ and Ⅲ, respectively. CONCLUSION: CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.
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    Histopathological and Immunohistochemical Characteristics of Breast Carcinomas in Uyo, Subtropical Region of Africa
    (Medical Journal of Zambia, 2019) Tanimowo, MO; Abudu, EK; Udo, IA; Abdulkareem, FB
    Background: There is a relative dearth of data for immunohistochemical characteristics of breast carcinomas in cancer registries of Nigeria and some parts of Africa. A descriptive hospital based study, done over a year, involving three hospitals in Uyo rendering breast cancer care. Objective: To determine the immunohisto chemical-expression pattern of oestrogen receptor, progesterone receptor, and human epidermal receptor 2 and their relationship with histopathological features of invasive breast carcinomas in Uyo, Akwa Ibom State. Materials and methods: Each specimen with an accompanying completely filled coded proforma form containing clinical characteristics of patients with breast cancer was received at the Histopathology Department for subsequent histopathological and immunohistochemical analysis. Results: The age range for patients with breast carcinoma was 23 -70 years with a mean age at presentation of43.07 ± 11.19 years. Invasive ductal carcinoma was the commonest histological type accounting for 86.9 % of all breast cancer. Positivity for oestrogen receptors, progesterone receptors and Her-2 were seen in 18.0 %, 14.8 % and 32.8 % of breast carcinomas respectively. Majority of breast carcinomas were triple negative phenotype (62.3 %). Conclusion: Majority of the invasive breast carcinomas in our environment were triple negative phenotype (62.3 %).
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    Open Access
    Malignant Gastrointestinal Tumours in South Western Nigeria: A Histopathologic Analysis of 713 Cases
    (West African Journal of Medicine, 2009) Abdulkareem, FB; Faduyile, FA; Daramola, A.O; Rotimi, O; Banjo, AAF; Elesha, SO; Anunobi, CC; Akinde, OR; Abudu, EK
    BACKGROUND: Malignant tumours of the gastro-intestinal tract are not as rare as previous studies suggest. Recent studies have indicated increasing incidence. OBJECTIVE: To document the pattern, age and sex distribution as well as histopathology characteristics of malignant tumours of the gastro-intestinal system in Lagos and Sagamu in Southwestern Nigeria. METHODS: The paraffin embedded blocks and slides as well as pathology reports of malignant tumours of the gastrointestinal (GIT) organs collected from five laboratories (Morbid Anatomy Departments of the Lagos University Teaching Hospital and Olabisi Onabanjo University Teaching Hospital in Sagamu, Ogun State as well as the three private histolopathology laboratories in Lagos State) were reviewed. The clinical data such as the age, sex, and clinical summary were extracted from the records. RESULTS: About 80% (578 cases) of all the 713 malignant GIT tumours were epithelial; sarcomas, carcinoid and non-Hodgkin’s lymphoma being less common. The ages ranged from 4–96yrs (mean of 48.9years) with the peak in patients 60–69-year age group and M:F ratio of 1.35:1. Colorectal tumours topped the list with 402 cases (56%), followed by liver 105(14.7%), stomach 85(12%) and omental metastases 67(9.4%). The oesophagus, pancreas, small intestine and gall bladder represented 18(2.5%), 16(2.2%), 12(1.7%), and eight (1.1%) respectively. Colorectal cancers peaked in the 60–69 year age group, liver and stomach cancer occurred mostly between the 50–59 years age group. Over half of the colorectal adenocarcinomata were located in the ano-rectum with 93(23%) occurring in those below 40 years of age. CONCLUSION: Colorectal cancer remains the commonest GIT tumour in the region. Molecular studies are imperative to identify the common subtypes of GIT tumours in order to ascertain their specific pathogenetic and prognostic features. WAJM 2009; 28(3) 173–176.
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    Open Access
    Pattern of Lymph Node Pathology in Lagos
    (Nigerian Quarterly Journal of Hopspital Medicine, 2011) Akinde, OR; Anunobi, CC; Abudu, EK; Daramola, AO; Banjo, A A F; Abdulkareem, FB; Osunkalu, VO
    Background: Enlarge lymph node is a common finding in clinical practice, which can be caused by several factors, such as infections, drugs etc. Objective: To review the pathology of lymph node diseases in children and adults with both deep seated and peripheral lymphadenopathy in Lagos. Methods: A 12- year retrospective study of lymph node biopsies at Histopathology Department of LUTH, and two main histopathology private laboratories in Lagos; The specialist Laboratory (TSL) and Histolab was carried out. Results: 733 samples of lymph nodes were seen. Of these, 229 (31.37%) were reactive, 109 (14.93%) were chronic granulomatuos lesions while lymphoma was seen in 123 cases (16.85%) and metastatic lesions in 269 cases (36.50%). The male to female ratio was 1:1.5. (286:436). In 670 cases, the lymph nodes were peripheral in location with the distribution of 249, 140 and 42 from the axilla, cervical and inguinal regions respectively. Only 60 of the samples were deeply seated lymph nodes; 55 from the intra-abdominal cavity and 5 from the mediastenium. About 239 samples did not have their sites indicated and majority of these (106) were diagnosed to be reactive lymphadenitis. Conclusion: The categories of lymphoid disease are similar to that of other third world countries but there is slight disparity in the frequency distribution of these diseases compared with findings in literatures within the countries.