Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: A histopathological review

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Abdulkareem, FB
Abudu, EK
Awolola, NA
Elesha, SO
Rotimi, O
Akinde, OR
Atoyebi, OA
Adesanya, AA
Daramola, AO
Banjo, AAF
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World Journal of Gastroenterology
AIM: To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria. METHODS: This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos & Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study. RESULTS: There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages Ⅱ and Ⅲ, respectively. CONCLUSION: CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.
Colorectal carcinoma; Adenocarcinoma; Pathological staging; Histopathological characteristics
World J Gastroenterol 2008 November 14; 14(42): 6531-6535