Impaired Appropriateness of Erythropoietin in Anaemic HIV Infected Patients
Date
2016
Authors
Olu-Taiwo, A
Amusu, A.O
Olatunya, O.S
Adediran, A
Ajayi, E.A
Ogbenna, A.A
Akanmu, A.S
Journal Title
Journal ISSN
Volume Title
Publisher
International Blood Research and Reviews
Abstract
This study was carried out to determine the degree of erythropoietin response in anaemic HIV
infected persons.
Methods: A total of 120 subjects were studied. These comprised of the study group made up of 40
HIV infected treatment naive patients who had anaemia with Haemoglobin level <10g/dL and 80
control subjects who were age and sex matched. The controls consisted of 20 HIV infected nonanaemic individuals, 40 non-HIV infected anaemic individuals, and 20 non-HIV infected nonanaemic individuals. Blood samples were collected for haemoglobin estimation, white cell count
and platelet count by automated counter. The CD4+ cell count was done by semi-automated flow
cytometer. The viral load was quantitated using PCR- based diagnostic tests and serum
erythropoietin level was estimated using ELISA technique. All patients gave written informed
consent with ethical approval by the hospital ethics and research committee.
Results: The study groups consisted of 40 males and 80 females. The mean age of male HIV
anaemic subjects (45.15±5.63, N=13) was significantly higher than that of the female HIV anaemic
subjects (34.16±7.21, N=25) p=0.005. The mean CD4+ cell count of HIV non-anaemic subjects
(530.55 cells/µL ±423.35) was significantly higher than HIV anaemic subjects (188.18 cells/µL
±157.09) (p=0.0009). Using regression equation the expected serum erythropoietin values for a
given haemoglobin level in HIV subjects was estimated. The appropriateness of erythropoietin level
was then determined and a ratio of <0.8 was considered inappropriate. Seventy one percent of the
HIV anaemic subjects had erythropoietin response ratio less than 0.8.
Conclusion: There was a blunted erythropoietin response for the degree of anaemia in HIV
compared with HIV negative subjects.
Description
Scholarly article
Keywords
Anaemia , HIV , treatment naïve , erythropoietin response , Research Subject Categories::MEDICINE
Citation
Olu-Taiwo, A., Amusu, A.O., Olatunya, O.S., Adediran, A., Ajayi, E.A., Ogbenna, A.A. and Akanmu, A.S. (2016). Impaired Appropriateness of Erythropoietin in Anaemic HIV Infected Patients. International Blood Research and Reviews, 6(10, 1-8.