Ikirydinium A: a new indole alkaloid from the seeds ofHunteria umbellata (K. Schum)
No Thumbnail Available
Date
2011
Authors
Ajala, O.S.
Piggott, A.M.
Plisson, F.
Khalil, Z
Huang, X.
Adesegun, S.A.
Coker, H.A.
Capon, R.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Abstract
Chemical investigations into samples ofHunteria umbellata(K. Schum) collected in Osun State, Nigeria,led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC500.6lM) againstBacillus subtilisATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized
Description
Keywords
Indole alkaloids , Hunteria umbellata , Nigerian medicinal plant , Natural products chemistry
Citation
Ajala, O. S., Piggott, A. M., Plisson, F., Khalil, Z., Huang, X. C., Adesegun, S. A., ... & Capon, R. J. (2011). Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum). Tetrahedron letters, 52(52), 7125-7127.