Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition
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Date
2019-11-08
Authors
Alaribe, S.C.
Esposito, T.
Sansone, F.
Adesegun, S.
Pagano, I.
Piccinelli, A.L.
Celano, R.
Cuesta Rubio, O.
Coker, H.A.
Nabavi, S.M.
Journal Title
Journal ISSN
Volume Title
Publisher
Natural Product Research Formerly Natural Product Letters
Abstract
Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together
with a promising antidiabetic effect against a-amylase and a-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.
Description
Scholarly article
Keywords
Nigerian propolis , polyphenols , free-radical scavenging activity , a-amylase and a-glucosidase enzymes , Research Subject Categories::PHARMACY
Citation
Alaribe, C. S., Esposito, T., Sansone, F., Sunday, A., Pagano, I., Piccinelli, A. L., Celano, R., Cuesta Rubio, O., Coker, H. A., Nabavi, S. M., Rastrelli, L., & Picerno, P. (2021). Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition. Natural product research, 35(18), 3095–3099. https://doi.org/10.1080/14786419.2019.1682576