• Green synthesis of Ag, Zn and Cu nanoparticles from aqueous extract of Spondias mombin leaves and evaluation of their antibacterial activity 

  Adeyemi, D. K; Adeluola, A. O; Akinbile, M. J; Johnson, O. O; Ayoola, G. A (AJCEM 2020, 2020-04)

  Background: Nanotechnology offers an advantage as a green route for synthesis of metal nanoparticles (NPs) with plant extracts as capping agent. Spondias mombin is a fruit-bearing tree and its leaf extracts have been ...

• Dissolution mechanism of tablets produced from coated lactose powder 

  Igwilo, C.I.; Pilpel, N. (1987)

  The use of the equation of Kitazawa et aJ in the analysis of the dissolution process of tablets produced from lactose powder coated with paraffin has suggested either an initial breaking of the tablets into particles that ...

• A consideration of the range and strength of interparticle forces in coated lactose powder 

  Igwilo, C.I.; Pilpel, N. (1988)

  A study has been made of the range and strength of interparticle forces in lactose powder coated with increasing concentrations of paraffins at different temperatures. Marked changes occurred in these forces as the paraffin ...

• Characterization of Chrysophyllum albidum Linn (Family: Sapotaceae) endosperm seed gum for potential application as pharmaceutical excipient 

  Ologunagba, M.O.; Azubuike, C.P.; Silva, B.O.; Sadiku, O.R. (Natural Product Research Group, University of Benin, 2017-11)

  The study was aimed at characterization of Chrysophyllum albidum seed gum (CasG) for potential application as a pharmaceutical excipient. Microwave-assisted technique was employed for CasG extraction using acetone as an ...

• Antimicrobial and physical properties of herbal ointments formulated with Methanolic extracts of Persea americana seed and Nauclea latifolia stem bark 

  Azubuike, C.P.; Obiakor, C.V.; Igbokwe, N.H.; Usman, A.R. (2014)

  Aims: In this study the antimicrobial and physical properties of herbal ointments formulated with methanolic extracts of Persea americana seeds and Nauclea latifolia stem bark were evaluated. Methodology: The preliminary ...

• Neutraceutical and antibacterial properties of methanol extract of Plukenetia conophora [Müll.-Arg. family Euphorbiaceae] leaves and physical properties of its cream formulations 

  Suara, K.O.; Azubuike, C.P.; Okubanjo, O.O.; Igwilo, C.I. (2016-04)

  The neutraceutical and antibacterial properties of methanol extract of the leaves of Plukenetia conophora were studied as well as physical properties of creams formulated with the extracts. Phytochemical analyses of the ...

• In vitro antisickling, antimicrobial and antioxidant potentials of extracts of Sorghum bicolor (L) Moench seeds and Mangifera indica (L) Anacardiaceae leaves and their formulations 

  Azubuike, C.P.; Uzoeto, C.A.; Igbokwe, N.H.; Igwilo, C.I. (Nigerian Association of Pharmacists in Academia, University of Benin Branch, Benin City, Nigeria., 2016-12)

  Purpose: Seeds of Sorghum bicolor (SB) and leaves of Mangifera indica (MI) are used in ethnomedicine in the management of sickle cell disorder (SCD). The present study involves phytochemical analysis of the methanolic ...

• Physicochemical properties and lubricant potentials of Blighia sapida Sapindaceaeae seed oil in solid dosage formulations 

  Aloko, S.; Azubuike, C.P.; Coker, H.A.B. (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria., 2017-02)

  Purpose: To investigate and compare the physicochemical properties and lubricant potentials of Blighia sapida seed oil (BSSO) with those of magnesium stearate, a commercial lubricant. Methods: The dried seeds of Blighia ...

• Characterization and evaluation of the suspending potentials of Corchorus olitorius mucilage in pharmaceutical suspensions 

  Azubuike, C.P.; Alfa, M.A.; Oseni, B.A. (Natural Product Research Group, University of Benin., 2017-07)

  The study was aimed at extraction, characterization and evaluation of suspending potentials of Corchorus olitorius mucilage (COM) in comparison with acacia BP (ACG) in pharmaceutical suspensions. Corchorus olitorius mucilage ...

• Extraction, microbial load and acute toxicity determinations of the exudate gum of Anacardium occidentale - A potential excipient in drug delivery. 

  Ologunagba, M.O.; Azubuike, C.P.; Silva, B.O. (2017-09)

  Natural polymers are increasingly used as excipients in formulation systems over the synthetics due to their comparative advantages. Exudate bark gum of Anacardium occidentale (family: Anacardiaceae) has been suggested for ...

• Extraction and characterization of the gum exudate of Anacardium occidentale for its potential as an excipient in drug delivery systems 

  Ologunagba, M.O.; Jain, S.; Thanki, K.; Suresh, S.; Furtado, S.; Azubuike, C.P.; Silva, B.O. (Natural Product Research Group, University of Benin, 2017-08)

  Natural polymers are preferentially used over synthetics as excipients in formulation systems. Characterization of a polymer is essential to determine its suitability as an excipient. This study aimed at extraction and ...

• Evaluation of the anti-candidal activity of the ointment formulation containing the admixture of Allium sativum (Liliaceae) and Citrus sinensis (Rutaceae) 

  Salako, K.S.; Silva, B.O.; Azubuike, C.P.; Salako, O.A. (2018-01)

  Candidiasis is a highly recurring disease with an history of resistance, thus the need for discovering newer anti-fungal drugs. The aim of this study was to evaluate the anti-candidal activity of the admixture of Allium ...

• Evaluation of the binding potential of Chrysophyllum albidum seed gum in paracetamol tablet formulation 

  Ologunagba, M.O.; Azubuike, C.P.; Sadiku, O.R.; Silva, B.O. (Natural Product Research Group, Faculty of Pharmacy, University of Benin, 2018-03)

  The seed gum of the endosperm of Chrysophyllum albidum has been reported to be a potential pharmaceutical excipient. The study aimed at the evaluation of the binding property of Chrysophyllum albidum seed gum (CasG) in ...

• Physicochemical and microbiological evaluation of acid modified native starch derived from Borassus aethiopum (Arecaceae) shoot 

  Azubuike, C.P.; Adeluola, A.O.; Mgboko, M.S.; Madu, S.J. (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria, 2018-05)

  Purpose: To evaluate the physicochemical properties and microbiological quality of Borassus aethiopum shoot acid-modified starch (AMS) for potential pharmaceutical applications. Methods: Modification of Borassus aethiopum ...

• Evaluation of acute and sub-chronic toxicities and the effect of ointment bases on the antimicrobial potency of the ethanolic extracts of Alchornea cordifolia Leaf and Terminalia superba stem bark 

  Igbokwe, N.H.; Echezonachi, E.P.; Azubuike, C.P.; Idowu, A.O. (Natural Product Research Group, Faculty of Pharmacy, University of Benin, 2018-07)

  The problem of resistance of dermatological infections to some antimicrobial agents available in the market has constrained man to search for newer compounds of natural origin with potent antimicrobials. Alchornea cordifolia ...

• Acute and sub-chronic toxicities and antimicrobial profiling of hydro-ethanol extracts of Moringa oleifera (L) seed in Swiss albino mice and Wistar rats 

  Igbokwe, N.H.; Ogbonnia, S.O.; Azubuike, C.P.; Idowu, A.O.; Orajiaka, S.C.; Ota, D.A. (Natural Product Research Group, Faculty of Pharmacy, University of Benin., 2018-07)

  Seeds and nuts have been employed since prehistoric era for their therapeutics and health benefits. Moringa oleifera (L.) is one of such seeds with poly-therapeutic activities and is consumed extensively in Nigeria for ...

• In Vitro Cytotoxic Effect of andrographolide On MDA-MB-231-LM2 breast cancer cells and its formulation and characterization as an emulsion 

  Oseni, B.A.; Azubuike, C.P.; Okubanjo, O.O.; Igwilo, C.I. (Natural Product Research Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria., 2019-11)

  Andrographolide, a potential chemotherapeutic agent elicits its anticancer activity on various cancer types by activating multiple cell death pathways thereby possessing the intrinsic ability to combat resistance. The ...

• Preliminary Studies on Binding Potentials of Defatted Cake Derived From Blighia Sapida Seeds in Ascorbic Acid Tablets 

  Azubuike, C.P.; Aloko, S. (2017)

  The physicochemical properties and binding potentials of defatted cake derived from Blighia sapida seeds (BSSC) were studied and compared with maize starch BP in ascorbic acid formulations. Milled seeds of Blighia sapida ...

• Comparative in vitro and in vivo Bioequivalence Analysis of some Brands of film coated Atorvastatin (a BCS Class II Compound) tablets marketed in Nigeria 

  Okorie, O.; Azubuike, C.P.; Ilomuanya, M.; Ubani‑Ukoma, U.N. (2016)

  The study is aimed at assessing the bioequivalence/quality of different brands of atorvastatin calcium 10mg tablets marketed in Nigeria. Physical parameters of the tablets, drug content, dissolution and pharmacokinetics ...

• Formulation and Evaluation of Antimicrobial Activities of Herbal Cream Containing Ethanolic Extracts of Azadirachta indica Leaves and Aloe Vera Gel 

  Azubuike, C.P.; Ejimba, S.; Idowu, A.O.; Adeleke, I. (2015)

  The antimicrobial activity of ethanolic extract of dried leaves of Azadirachta indica (Neem), fresh gel of Aloe vera, combination of the two extracts and the creams formulated with these extracts were evaluated. The ...

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