Comparative cytotoxicactivity of selected Nigerian medicinal plant extracts on Ehrlich ascites carcinoma cells
Date
2019
Authors
Lawal, R.A.
Ozaslan, M.
Adisa, R.A.
Odesanmi, O.S.
Karagoz, I.D.
Kilic, I.H.
Ebuehi, O.A.T.
Journal Title
Journal ISSN
Volume Title
Publisher
LASU Journal of Health Sciences
Abstract
Background: Nigerian medicinal plants have long been reported to manage cancer and its symptoms. Some of the frequently mentioned plants used for the treatment of cancer reported in Nigerian Ethnobotanical surveys include Securidaca longepedunculata, Tetrapleura tetraptera, Morinda lucida, Spondias mombin and Nymphaea lotus. The cytotoxicities of some of these plants have been reported in literature. However, there is no comparison of the cytotoxicities of these plants on Ehrlich ascites carcinoma (EAC) cells. This research aims to compare the in vitro cytotoxic activities of the anti-cancer plants using EAC cells.
Method: Aqueous extracts of Securidaca longepedunculata, Tetrapleura tetraptera, Morinda lucida, Spondias mombin and ethanol extracts of Tetrapleura tetraptera, Spondias mombin, Nymphaea lotus were prepared. The different extracts were used to test for cytotoxicity on Ehrlich ascites carcinoma cells using the Trypan blue dye exclusion principle.
Results: All extracts caused dose-dependent increase in mortality of EAC cells. IC50 values of the extract range from 11.48 for Aqueous extract of Tetrapleura tetraptera to 2691μg/ml for ethanol extract of Nymphaea lotus. Conclusion: Aqueous extract of Tetrapleura tetraptera was the most cytotoxic with an IC50 of 11.48 μg/ml compared to 5-fluorouracil with 2.88 μg/ml.
Description
Staff publications
Keywords
Securidaca longepedunculata , Spondias mombin , Tetrapleura tetraptera , Nymphaea lotus , Morinda lucida , cytotoxic , plants , Nigeria , Research Subject Categories::MEDICINE::Chemistry::Biochemistry
Citation
Lawal, R.A., Ozaslan, M., Adisa, R.A., Odesanmi, O.S., Karagoz, I.D., Kilic, I.H., & Ebuehi, O.A.T. (2019). Comparative cytotoxicactivity of selected Nigerian medicinal plant extracts on Ehrlich ascites carcinoma cells. LASU Journal of Health Sciences, Vol.2(2).