Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: A histopathological review
Date
2008
Authors
Abdulkareem, FB
Abudu, EK
Awolola, NA
Elesha, SO
Rotimi, O
Akinde, OR
Atoyebi, OA
Adesanya, AA
Daramola, AO
Banjo, AAF
Journal Title
Journal ISSN
Volume Title
Publisher
World Journal of Gastroenterology
Abstract
AIM: To study the frequency, gender and age
distribution as well as pathological characteristics of
colorectal carcinoma (CRC) in Lagos and Sagamu in
SW Nigeria.
METHODS: This is a retrospective pathological review
of histologically diagnosed CRC from 5 laboratories in
Lagos & Sagamu. The clinical data, such as age, sex
and clinical summary were extracted from demographic
information. Cases of anal cancer were excluded from
this study.
RESULTS: There were 420 cases (237 males and
183 females) of CRC. It peaked in the 60-69 year
age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1
and 23% occurred below 40 years. The majority was
well to moderately differentiated adenocarcinoma
321 (76.4%), mucinous carcinoma 45 (10.7%)
and signet ring carcinoma 5 (1.2%), and more
common in patients under 40 years compared to well
differentiated tumors. The recto-sigmoid colon was the
most common site (58.6%). About 51% and 34% of
cases presented at TNM stages Ⅱ and Ⅲ, respectively.
CONCLUSION: CRC is the commonest malignant
gastrointestinal (GIT) tumor most commonly located in
the recto-sigmoid region. The age and sex prevalence
and histopathological features concur with reports
from other parts of the world.
Description
Keywords
Colorectal carcinoma; Adenocarcinoma; Pathological staging; Histopathological characteristics
Citation
World J Gastroenterol 2008 November 14; 14(42): 6531-6535