Anti-Inflammatory properties of the fruit of allanblanckia floribunda oliv. (Guttiferae)
Date
2009
Authors
Ayoola, GA.
Akpanika, GA.
Awobajo, FO.
Sofidiya, MO.
Osunkalu, VO.
Coker, HAB.
Odugbemi, TO.
Journal Title
Journal ISSN
Volume Title
Publisher
Botany Research International
Abstract
The present study aims to investigate the anti-inflammatory properties of the fruits of Allanblackia floribunda Oliv. [Guttiferae]. The fruits are traditionally used in the treatment of anti-inflammatory conditions. The methanolic extracts of the fruits (100-400 mg/kg, p.o) inhibited carrageenan induced paw oedema in rats in a dose dependent manner. At 400 mg/kg A. floribunda(AF) produced an inhibition of 76.9% compared to 64.3% for indomethacin (10 mg/kg). Acetylsalicylic acid(100 mg/kg - ASA) did not show significant activity in the inhibition of the neurogenic phase, butwas more active thanA. floribunda in the inhibition of the inflammatory phase of formalin-induce pain.A. floribunda was not active as an anti-inflammatory agent up to 2 h in the histamine-induced rat paw oedema but a significant reduction in paw size was observed after 2 h. This suggests that AF was more active in the later phase of the inflammatory process. AF also reduced hot plate latency in a dose dependent manner. Hot plate latency of 26.8 s was recorded for AF at 400 mg/kg compared to 18.12 s for normal saline and 30.6 s for ASA. LD,, value was determined in Swiss albino mice as 20 g/kg and so can be regarded as relatively safe.
Description
Staff Publications
Keywords
Allanblackia floribunda , Anti-inflammatory , Rat paw oedema , Analgesic , Research Subject Categories::MEDICINE
Citation
Ayoola GA, Akpanika GA, Awobajo FO, Sofidiya MO, Osunkalu VO, Coker H.A. & Odugbemi TO (2009). Anti-Inflammatory properties of the fruit of allanblanckia floribunda oliv. (Guttiferae). Botany Research International, 2(1):21-26.