Synthesis and antibacterial screening of 2-hydroxybenzylidene-aminophenols and its cu(II) complexes

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dc.contributor.authorElijah, F.N.
dc.contributor.authorFasina, T.M.
dc.contributor.authorRevaprasadu, N.
dc.contributor.authorOgunsola, F.T.
dc.contributor.authorFamiloni, O.B.
dc.date.accessioned2020-01-14T12:09:56Z
dc.date.available2020-01-14T12:09:56Z
dc.date.issued2015
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: The design of metal containing antimicrobial agents is currently of interest due to the growing reports of drug resistance for known antimicrobial agents. Structure activity relationship is crucial in the investigation of potential candidates in drug therapy. Objective: In line with the structure activity relationship, a new series of copper (II) complexes of Schiff base 2-hydrobenzylidene 2-aminophenol (L1), 2-hydroxybenzylodene-3-aminophenol (L2), and 2-hydroxybenzylodene-4-aminophenol (L3) have been synthessied. The goal of this study was to investigate the effect of position of substituent on the antibacterial activities of the ligands and its meta complexes. Methods: The compounds were prepared using condensation method. Structural and spectroscopic properties were studiued by elemental analysis, spectral (FR-IR, 1HNMR, UV-Vis) and magnatic susceptibility measurements. The Schiff base ligands and its complexes were screened in-vitro against E. coli, S. aureus, P. aeruginosa, B. cereus, E. faecalis and K. pneumonia bacteria. Results: The metal complexes exhibited higher antibacterial activities than the parent ligand. This can be attributed to the greater lipophilic natue of the complexes. Conclusion: The results show that the investigated metal complexes can be employed as broad spectrum antibacterial agents.en_US
dc.identifier.citationElijah, F.N, Fasina, T.M, Revaprasadu, N, Ogunsola, F.T. Familoni, O.B. (2015). Synthesis and Antibacterial screening of 2-Hydroxybenzylidene-Aminophenols and its Cu(II) Complexes. University of Lagos, Journal of Basic medical Sciences, 3: 7-13.en_US
dc.identifier.urihttps://www.google.com/search?q=Synthesis+and+antibacterial+screening+of+2-hydroxybenzylidene-aminophenols+and+its+cu(II)+complexes&oq=Synthesis+and+antibacterial+screening+of+2-hydroxybenzylidene-aminophenols+and+its+cu(II)+complexes&aqs=chrome..69i57.3299j0j7&sourceid=chrome&ie=UTF-8
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7371
dc.language.isoenen_US
dc.relation.ispartofseriesUniversity of Lagos, Journal of Basic medical Sciences;Vol.3
dc.subjectAntimicrobial agentsen_US
dc.subjectCopper (II)en_US
dc.subjectMetal complexen_US
dc.subjectSchiff baseen_US
dc.subjectAminophenolen_US
dc.subjectResearch Subject Categories::MEDICINE::Microbiology, immunology, infectious diseasesen_US
dc.titleSynthesis and antibacterial screening of 2-hydroxybenzylidene-aminophenols and its cu(II) complexesen_US
dc.typeArticleen_US
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