Pharmaceutical Chemistry- Scholarly Publications

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Browsing Pharmaceutical Chemistry- Scholarly Publications by Author "Abioye A.O."

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    Open Access
    Interaction between Ciprofloxacin and some metal ions.
    (J. Pharm. Sci. & Pharmaceut. Prac., 2009) Adepoju-Bello A.A.; Coker H.A.B.; Abioye A.O.; Ayoola G.A.
    Purpose: Solid state synthesis of a compound is not so common. Concomitant administration of quinolones with metal ion containing drug preparations, food supplements and fruit juices have been reported to cause a reduction in the activity of quinolones. Objective: This study was carried out to determine if there is an interaction between ciprofloxacin and the metal ions in the solid state. Method: Divalent, Zn2+, Cu2+ and trivalent, Al3+, were used for the study. The pure ciprofloxacin (CIP)sample, triturated fluoroquinolone and metal ion in the solid state and the metal ions were analysed using FT-IR spectrophotometer. Result: The results obtained showed a carbonyl absorption band at 1708.2 cm-1 for ciprofloxacin, which was absent on the ciprofloxacin-metal complex infrared spectrum indicating an interaction. Conclusion: There was an interaction between ciprofloxacin and the metal ions at the solid state.
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    Open Access
    The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex.
    (Nig. Q. J. Hosp. Med., 2008) Adepoju-Bello A.A.; Coker H.A.B.; Eboka C.J.; Abioye A.O.; Ayoola G.A.
    Purpose: Co-administration of quinolone antibiotics with cation-containing medicaments such as, antacids has been reported to influence the overall bioavailability leading to subtherapeutic plasma concentrations of these antibiotics in humans. Objectives of the study: The present work was designed to evaluate the binding constant, binding molar ratio, influence of temperature on the binding constant of ciprofloxacin-Mg2+ and to determine the antimicrobial activity of ciprofloxacin and ciprofloxacin-Mg2+. Methods: Job's method of continuous variation and Benesi-Hildebrand equation were adopted to determine the molar ratio and stability constant respectively. The antibacterial activity was determined.by the Agar diffusion method. Results: A complexation molar ratio of 1 :1 was obtained for ciprofloxacin-Mg2+ complex. The stability constants were 3.59 and 3.50 at 25°C and 60°C respectively. There was a significant difference between the zones of inhibition of ciprofloxacin-Mg2+ complex and that of ciprofloxacin alone against E. coli, P. aeruginosa and S. aureus (p<0.05). This difference showed that the complex formed was not as active as ciprofloxacin. Conclusion: The present studies have shown that ciprofloxacin readily complex with Mg2+ and that the stability constant was temperature dependent. The antibacterial activity of ciprofloxacin was markedly reduced in the presence of Mg2+. Concomitant administration of ciprofloxacin Mg2+ containing medicaments should be avoided to prevent resistance. Key words: Ciprofloxacin-Mg2+ complex, stability constant, antibacterial activity.
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    Open Access
    Solid state interaction of Pefloxacin with Zinc and Aluminium metal ions using Fourier Transform-Infrared spectroscopy.
    (Nig. Qt J. Hosp. Med., 2011) Adepoju-Bello A.A.; Coker H.A.B.; Abioye A.O.; Ezeagu I.I.; Ayoola G.A.
    Background: Interaction between compounds in solvent medium is very common but reactions between compounds at the solid state are not common. It was reported that co-administration of quinolones with metal ion containing drug preparations, food supplements and fruit juices results in a reduction in bioavailability and the activity of quinolones. It was established, in vitro, that fluoroquinolones interact with metal ions and the antibacterial activity of the complex formed was lower than that of the pure fluoroquinolone . Objective: The objective of this study is to carry out an interaction between pefloxacin and some metal ions at the solid state without a solvent medium. Methods: Zn2+· and-Al3+ salts were used for the study. Pure pefloxacin was triturated with the metal ion salts at the solid state and the products obtained were analysed using fourier Transform-Infrared spectrophotometer. The spectra obtained were compared with that of pure pefloxacin. Results: A carbonyl absorption band at 1707 cm-1 was observed on pure pefloxacin spectrum. This band was not found on the pefloxacin-metal complexes' spectra. The disappearance of this band on the pefloxacin-metal complexes' spectra indicates an interaction at the carbonyl group with the metal ion without a solvent medium. Conclusion: Pefloxacin reacted with Zn2+ and Al3+ metal ions at the solid state.