Oral and Maxillofacial Surgery - Conference Papers

Permanent URI for this collection

https://ir.unilag.edu.ng/handle/123456789/4522

Browse

Browsing Oral and Maxillofacial Surgery - Conference Papers by Issue Date

Filter results by year or month
Now showing 1 - 12 of 12
  • Item
    Open Access
    Genetics of lower third molar impaction and its association with height of an individual
    (Faculty of Dental Sciences Conference 2017, 2017-07-06) Adeyemo, W.L.; James, O.; Oladega, A.A.; Adamson, O.O.; Olorunsola, K.D.; Butali, A.
    Aim: To evaluate the relationship between height and presence of impaction of third molars. To also determine the role of genetics in third molar impaction by correlation with candidate genes reported to be associated with height, jaw growth and tooth agenesis. Material and methods: Cases consisted of subjects with third molar impaction; and controls were those without third molar impactions. Height of subjects was measured in metres; and saliva samples were also collected from all subjects. DNA was extracted from saliva samples. Taqman Genotyping using SNPs identified for jaw growth, height and tooth agenesis was employed. A total of 5 candidate genes were investigated using 11 SNPs. We conducted case-control analyses to determine association using PLINK. For this test, we used P < 0.05 to denote significant association. Results: There were 200 cases and 200 controls. The mean height of cases (1.68 0 ±.09 metres) was significantly lower than that of the controls (1.70 ± 0.09 metres) (P=0.04). No difference was found in allele frequency between cases and controls for 10 of the 11 SNPs. However, for rs6504591 the P-value was near significance (P= 0.07) with Odd Ratio of 2.131. Conclusions: Subjects with lower third molar impactions were significantly shorter than those who have fully erupted third molars. The rs6504591 G/T variation on human chromosome 17 (WNT9B gene) appears to increase for impaction albeit with limited power to detect significance. This suggests that with an increase in sample size and adequate power, we will be able to detect significance for this gene. Keywords: Third molars; impactions; height; genetics; WNT9B
  • Item
    Open Access
    Paternal uniparental disomy on chromosome 22 and a de-novo deletion on chromosome 18 in individuals with orofacial clefts.
    (Unilag Press, 2017, 2017-08-15) Adeyemo, W.L.; James, O.; Ogunlewe, M.O.; Oseni, G.O.; Jain, D.; Mossey, P.A.; Busch, T.; Gowans, L.J.J.; Eshete, M.A.; Laurie, C.A.; Olaitan, P.B.; Aregbesola, B.S.; Bello, S.A.; Abdur-Rahman, L.; Marazita, M.L.; Murray, J.C.; Adeyemo, A.A.; Butali, A.
    Background: Orofacial clefts are the commonest malformations of the head and neck region. Genetics, genomics and environmental factors have been implicated in the aetiology of these traits. Objective: Although paternal and maternal uniparental disomy (UPD) in clefts are very rare, they have been reported on chromosomes 6, 7, 10, 12,15 16 and 21. However, none has been reported on chromosome 22. To identify variation associated with non-syndromic clefts in sub-Saharan African population, we recently genotyped samples from affected cases, cases families and unrelated controls. The aim of study is to report cases of sex aneuploidies, trisomies, chromosomal anomalies, large deletions and duplications detected in our analysis. Methods: The recruitment of eligible individuals and families has been published (Butali et al., 2011; Gowans et al., 2016). Ethical approval was obtained from the Institutional Review Boards at the Kwame Nkrumah University of Science and Technology, Lagos University Teaching Hospital Idi-Araba, Lago, Obafemi Awolowo University Teaching Hospital Ile-Ife and the Addis Ababa University. We used the multi-ethnic genotyping array (MEGA) to identify genetic variation associated with non-syndromic clefts. The data cleaning of this dataset allowed for screening of annotated sex versus genetic sex, confirmation of identify by descent and identification of large chromosomal anomalies. Results: During data cleaning, we identified the first case of paternal uniparental disomy (patUPD) on chromosome 22. We also identified a de-novo deletion on chromosome 18. In addition to chromosomal anomalies, we identified cases with Klinefelter syndrome, Turner syndrome and Triple X syndrome. Conclusion: Observations from our study support the need for genetic testing in order to exclude chromosomal anomalies associated with clefting. The identification of these chromosomal anomalies and sex aneuploidies is very important in genetic counselling for families that are at risk. Therefore, clinicians should be mindful of the fact that not all isolated clefts are complex traits. Clinicians should also endeavor to share this information with families during routine clinical visits and evaluations. Keywords: Disomy; Paternal; Uniparental; Orofacial Clefts; Deletion
  • Item
    Open Access
    Association of Dickkopf-1 (DKK1) Mutations with Non-syndromic Orofacial Clefts in African Populations
    (Pan Arab Human Genetics Conference 2018, 2018-01-18) Adeyemo, W.L.; Lo, C.; James, O.; Busch, T.; Butali, A.
    Background and Purpose: Orofacial cleft (OFC) has both genetic and environmental. In studies with mice, when the TGFβ gene was knocked out, orofacial clefts resulted because the absence of the TGFβ gene led to upregulation of DKK1. However, the role of DKK1 in human orofacial clefts remains unclear. The purpose of this study was to identify certain loci in the DKK1 gene associated with non-syndromic OFCs in humans in order to further research about the genetic aetiology of clefts. Method: Two hundred and eighty-eight cleft lip and palate (CLP) samples and 192 cleft palate only (CPO) saliva samples were collected from Ghana, Ethiopia, and Nigeria and sequenced. Then, using the programs Primer 3, UCSC Genome Browser, and BLAT, primers were designed for the four DKK1 exons to be used for PCR. DNA was extracted from the collected saliva samples and underwent PCR to be amplified and used for sequencing. Using the computer program Consed, each individual’s nucleotide sequence acquired from Sanger Sequencing was compared to a reference sequence to identify variants. Once variants were identified, SIFT and Polyphen and HOPE were used to predict the degree of damage caused by the mutation. Results: One novel missense mutation was found on the fourth exon of DKK1 in an individual from the Ghana CLP population, and one known missense mutation (rs140471040) was found on the first exon of DKK1 in two individuals from the Ghana CLP population and four individuals from the Africa CPO population. The known missense mutation resulted in the amino acid change p. Met16Leu, and was predicted to be tolerated and benign. Conclusions: The novel variant found in one individual from the Ghana CLP population creates an association between DKK1 and non-syndromic orofacial clefts in humans, demonstrating the interactions between multiple signaling pathways in the aetiology of orofacial clefts. Keywords: DKK1; Orofacial clefts; Africans
  • Item
    Open Access
    Genome-wide analysis refines the genetic architecture of orofacial clefts and identifies novel risk loci in the african population.
    (Unilag Press, 2018, 2018-08-28) Adeyemo, W.L.; James, O.; Ogunlewe, M.O.; Oseni, G.O.; Jain, D.; Mossey, P.A.; Busch, T.; Gowans, L.J.J.; Eshete, M.A.; Laurie, C.A.; Olaitan, P.B.; Aregbesola, B.S.; Bello, S.A.; Abdur-Rahman, L.; Marazita, M.L.; Murray, J.C.; Adeyemo, A.A.; Butali, A.
    BACKGROUND: Orofacial clefts (OFCs) are the most common birth defects in the head and neck region, affecting one out of every 700 live births worldwide. These defects lead to significant financial, educational, medical, psychological, and cultural problems. OBJECTIVE: To conduct genome wide association study (GWAS) for OFC in Africa. METHODS: A total of 3,353 participants were genotyped on the pre-release consortium version of Illumina Multi Ethnic Genotyping Array (MEGA). Imputation was done into the 1000 Genomes Phase 3 reference imputation panel using IMPUTE2. The final dataset that passed quality control consisted of 3,178 participants enrolled from Ethiopia (30%), Ghana (43%), and Nigeria (27%). They included 814 cases of CLP, 205 cases of isolated CP, and 2,159 related and unrelated controls. Over 45million SNPs were imputed including the 2.2million SNPs in the Multi Ethnic Genotyping Array. Of these SNPs, only 16 million passed our quality control filter and were included in the final analyses. Given the known differences in the developmental and genetic basis of CL/P versus isolated CP, we conducted two separate GWAS (one for each phenotype). RESULTS: The GWAS for CL/P showed that the most significant hits are on chromosomes 8 and 3. The chromosome 8 locus (leading SNP, rs72728755, p = 1.52 × 10–6) is in the 8q.24 region that has been previously reported to be associated with CL/P in Europeans. The GWAS for isolated CP revealed one genome-wide significant locus on chromosome 2 (leading SNP rs140938806, p = 2.76 × 10–9). CONCLUSIONS: Our study has refined the genetic architecture of OFC in Africa, identified new loci and demonstrated genetic heterogeneity for the two cleft sub-phenotypes. This will lead to additional insights into craniofacial development and biology. Keywords: Orofacial clefts; GWAS, Africa
  • Item
    Open Access
    A comparative study of cyanoacrylate tissue adhesive and silk suture for closure of surgical wound following removal of an impacted mandibular third molar: a randomized controlled study.
    (Unilag Press, 2018, 2018-08-28) Oladega, A.A.; James, O.; Adeyemo, W.L.
    Background: Suturing is the conventional method of wound closure following third molar surgery. However, it increases surgical time, causes trauma to soft tissue and there is usually need for second appointment to remove the sutures. Objective: To evaluate and compare postoperative sequelae and wound healing outcome following closure of surgical wound with either cyanoacrylate tissue adhesive or silk suture. Methods: Patients with impacted mandibular third molar who presented in the clinic for therapeutic extraction, met the inclusion criteria and gave informed consent were recruited for the study. Surgical extraction was done using buccal guttering technique under local anaesthesia. Subjects were randomized into 2 groups; silk suture (group A) and cyanoacrylate (group B), with 60 in each group. Post-operative pain, swelling, trismus, bleeding, wound dehiscence and wound infection were evaluated. Results: There was no statistically significant difference in the age and gender distribution between the 2 groups. No significant difference was observed in the mean post-operative pain, swelling and mouth opening ability between the 2 groups. There was statistically significant difference in bleeding between the 2 groups on post-operative day 1, with more bleeding in group A. The incidence of wound infection and dehiscence was not statistically significant between the 2 groups. Conclusions: This study shows that cyanoacrylate tissue adhesive compares favourably with silk suture as a wound closure material. It may therefore be a suitable alternative to suturing for wound closure following extraction of an impacted lower third molar. In addition, cyanoacrylate tissue adhesive seems to have beneficial haemostatic effect on post-operative bleeding. Keywords: Silk suture; Cyanoacrylate tissue adhesive; Impacted third molar
  • Item
    Open Access
    Assessment of predictors of treatment outcome among patient with bacteria odontogenic infection
    (Unilag Press, 2018-08-28) Adamson, O.O.; Gbotolorun, O.M.; Odeniyi, O.; Oduyebo, O.O.; Adeyemo, W.L.
    Despite the increasing availability of antimicrobial therapy and healthcare services, odontogenic orofacial infections remain a cause of admission and mortality of patients. Subjects who presented with bacterial odontogenic orofacial space infection and satisfied inclusion criteria were included. Incision and drainage/decompression was performed for all anatomic fascial spaces that were involved. All subjects received empirical antibiotics and MCS samples collected were cultured for aerobic and anaerobic organisms. There were 30 males and 25 females with a male-to-female ratio of 1.2:1. Of the 55 cases seen, majority (39) presented with abscess, 7 with Ludwig’s angina and 5 with necrotising fasciitis. Forty-two (76.4%) of specimen sent for MCS yielded positive culture for bacteria. Gram negative aerobes (25) were the most common bacteria and the least isolated were anaerobes (8). Overall, 52% of isolated organisms were sensitive to amoxicillin-clavulanate, 70% were sensitive to Ceftriaxone while 24% were resistant to both antibiotics. Subjects with clinical diagnosis of abscess or cellulitis were more likely to have a successful outcome without complications. The only significant predictors of outcome were haemoglobin level and number of spaces involved. Organisms involved in odontogenic infections were more sensitive to Ceftriaxone making it a better empirical antibiotic to Amoxicillin-clavulanate for severe odontogenic infections. Subjects with clinical diagnosis of abscess or cellulitis were more likely to have a successful outcome than those with necrotising fasciitis or Ludwig’s angina. Haemoglobin level and number of spaces involved were the only significant predictors of outcome. KEYWORDS: Bacterial, Odontogenic, Orofacial space, Infections, Sensitivity, Outcome
  • Item
    Open Access
    Neurosensory deficits of inferior alveolar nerve following impacted mandibular third molar extraction: comparison of a two stage versus one stage surgical technique
    (Unilag Press, 2019, 2019-08-21) James, O.; Oyeneyin, A.O.; Adeyemi, M.O.; Adeyemo, W.L.
    Background: Surgical extraction of impacted mandibular third molar (3M) may be associated with post-operative complications. Inferior alveolar nerve (IAN) neurosensory deficits in form of paraesthesia of lower lip and gingivae is a common complications which impacts negatively on the quality of life of the patients. Landi et al has proposed two stage surgical extraction as an alternative surgical procedure to reduce this complication. However, few published studies on staged partial coronectomy are only case reports and case series. Aim and Objectives: To compare neurosensory deficits of inferior alveolar nerve following impacted mandibular third molar extraction using either a two stage or one stage surgical technique. Material and methods: This randomized controlled study was conducted at the Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital (LUTH) Idi Araba, Lagos State, Nigeria between April 2016 and September 2018. Subjects with mesioangular or horizontal impacted 3M with intimate relationship with inferior alveolar canal who met the inclusion criteria were recruited for the study and informed consent obtained. Surgical extraction was done under local anaesthesia using buccal guttering technique. Subjects were divided into 2 groups (one-stage technique and two-stage technique). The subjects were evaluated for the presence of IAN neurosensory deficit and recovery, as well as the relationships of IAN neurosensory deficits with gender, age and type of impaction. Results: A total of 68 subjects who satisfied the inclusion criteria participated in the study with 34 subjects in each group. There were 33 (48.5%) males and 35 (51.5%) females. The age range of participants was 18-57years with a mean age of 28.07 ± 8.37. There was not statistically significant difference in the age and gender distribution between the 2 groups. Neurosensory deficit of IAN was observed in 6 subjects, comprising of 5 (14.7%) in group A and 1 (3.33%) in group B. This difference was not statistically significant (p=0.23). Temporary nerve deficit was observed in 5 cases while permanent nerve deficit was seen in one patient. Similarly, relationships between the incidence of IAN neurosensory deficit and age, gender, type; position; and class of impaction, and the relationship between the proximity of the root with IAN were found not to be related to the neurosensory deficit outcomes age, gender and type of impaction in both groups were not statistically significant. Conclusion: This study shows that two-stage surgical extraction technique of impacted 3M was associated with lower incidence of IAN injury when compared with conventional one stage technique. The difference was however, not statistically significant. Two-stage surgical technique may be a suitable alternative to one stage surgical extraction technique of impacted 3Ms at risk of IAN injury especially when cost of treatment is taken into consideration.
  • Item
    Open Access
    Breast feeding practices among mothers of children with oro-facial cleft in an African cohort.
    (Unilag Press, 2019, 2019-08-21) Adekunle, A.A.; Adamson, O.O.; James, O.; Adeyemo, W.L.; Ogunlewe, M.O.
    Background The challenge of breastfeeding in infants with cleft lip is achieving a seal around the nipple, but this can still be achieved with some effort, a cleft of the palate on the other hand makes it difficult to achieve the required intra oral negative pressure to suck, making feeding more challenging in this population which may result in inadequate nutrient intake (Chen et al. 1990; Ize-Iyamu and Saheeb 2011; Miller 2011).There is limited literature from our environmentabout breastfeeding practices among mothers of babies with oro-facial cleft. Objective:The study was carried out toassess the breastfeeding practices among mothers of children born with oro-facial cleft. Methodology: This was a cross sectional descriptive study using an interviewer administered questionnaire. Sample population was all mothers of babies aged between 1 and 18 months with non -syndromic oro-facial cleft attending the cleft clinic of the department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Idi-araba, Lagos. Result: A total of 65 mothers participated in the study. Initiation of breastfeeding was reported by majority (83%, n=54) of the mothers, however, only 18.5%(n=10) of this proportion continued exclusive breastfeeding. Inability of the babies to suck was reported by 46% (n=30) of the mothers as being the most important challenge in breast feeding. There was a significant correlation between type of cleft and challenge in breastfeeding (fishers exact P = 0.001). Sixty three percent (n= 41) of the mothers reported they received no counselling on overcoming challenges associated with feeding their babies with a cleft at the facility where they delivered. Sixty nine percent (n=45) reported they first received nutritional information from the cleft clinic at presentation. The most commonly adopted substitute for breastfeeding was the use of regular feeding bottles (n=24, 43.6%). Conclusion:Rate of initiation of breastfeeding for children with oro-facial cleft in this African cohort is higher than reported in other populations despite the low level of nutritional counselling of the mothers after delivery.
  • Item
    Open Access
    Cardiovascular anomalies in patients with oro-facial clefts: a prospective case controlled study
    (Unilag Press, 2019, 2019-08-21) James, O.; Sokunbi, O.J.; Agbogidi, F.O.; Adekunle, A.A.; Ogunlewe, A.O.; Ekure, E.N.; Adeyemo, W.L.; Ladeinde, A.L.; Ogunlewe, M.O.
    BACKGROUND Orofacial clefts are among the most common birth defects, occurring in about 1.7 per 1000 newborns (Correia-Costa et al 2010). The reported incidence varies with different studies, however a nationwide hospital-based study in Nigeria reported a prevalence of 0.5 per 1000 live-birth (Butali et al 2014). This heterogeneous group of disorders can occur as an isolated condition or in association with other congenital anomalies or syndromes (Rittler et al 2008; Altunhan et al 2012; James et al 2014;). The frequency and type of associated malformations observed varies considerably across studies (Hagberg et al 1998; Stoll et al 2000; Wehby and Murray 2010; James et al 2014). The study by Hagberg et al (1998) indicated that 21–37% of orofacial cleft patients have other anomalies of which 24–51% involved the cardiovascular system. Cardiovascular anomaly is always a concern in a child born with a cleft palate (Fillies et al 2007; Sekhon et al 2011; Harry et al 2013). This anomaly may have an impact on the timing of cleft repair and the need for sub-acute bacterial endocarditis prophylaxis (Fillies et al 2007). The presence of these anomalies may mandate cardiac surgery before cleft repair (Fillies et al 2007). Cardiac anomaly may also impact on the incidence of anaesthetic risk/complication during surgery under general anaesthesia (Shprintzen et al 1985; Fillies et al 2007). The incidence and pattern of cardiac anomalies associated with orofacial cleft in our environment is also still unknown. It is therefore important to identify the types of cardiac anomalies and their pattern of presentation in Nigerian patients. The result of this study will provide baseline information on the incidence and pattern of presentation of cardiovascular anomalies in Nigerian subjects with congenital oro-facial cleft and possibly facilitate the development of a surgical management protocol for cleft patients with the cardiac abnormalities. AIM: To study the prevalence and pattern of cardiovascular anomalies in a population of patients with orofacial clefts and compare with those of age and sex matched control subjects. METHODOLOGY This study was conducted at the Oral and Maxillofacial Surgery Cleft Clinic, Pediatric and Community Health Outpatient Clinics of the Lagos University Teaching Hospital. Subjects were all consecutive cleft lip and palate subjects aged 2 months and above. Age and sex matched control subjects who are without cleft lip and palate were also recruited. All eligible subjects (cases and controls) who attend the cleft lip and palate clinic of the hospital had a full clinical examination done at the first visit and during subsequent review appointments. Socio demographic characteristics of the patients and other variables as well as other relevant clinical information about the cleft lip and palate disorder was recorded on a proforma As part of the evaluation, cardiovascular assessment was carried out on all the subjects (case and control) by a Pediatric Cardiologist. All subjects thereafter had electrocardiography (ECG) and Echocardiography tests done. The results were then interpreted by the pediatric cardiologist. The systemic assessment, ECG and echocardiography report was documented in another profoma. RESULT: A total of 120 subjects who satisfied the inclusion criteria participated in the study with 60 subjects in each group. There were 63 (52.5%) males and 57 (47.5%) females with a male-to-female ratio of 1.1:1. Of the 60 subjects in the oro-facial cleft group, 14 (23.3%) had bilateral cleft lip and palate, 12(20%) had unilateral cleft lip and palate, 13(21.7%) had isolated cleft of the palate. Four (6.67%) of the control subjects was diagnosed with congenital heart defects while 17(28.3%) of the oro-facial cleft group had congenital heart defect (p=0.001) Conclusion: This study shows a statistically significant higher incidence of cardiovascular anomalies in subjects with orofacial clefts than age and sex matched control subjects.
  • Item
    Open Access
    Evaluation of speech therapy outcome on patients with cleft lip and palate after surgical repair at LUTH
    (FDS, CMUL, 2019-10-09) Ayelomi, O.I.; Adamson, O.O.; Babatunde, A.A.; James, O.; Adeyemo, W.L.; Ladeinde, A.L.; Ogunlewe, M.O.
    Backgroud: Some patients have persisting speech deficiencies after cleft surgery. Speech therapy is often carried out in order to correct this problem. Aim: To evaluate the outcome of speech therapy in patients following cleft lip and palate surgery. Materials and methods: A retrospective review of medical records of post cleft surgery patients who had speech therapy from July 2018 - July 2019, at the Lagos University Teaching Hospital. The following information was obtained: demographics, type of cleft, speech defects, treatment objectives and strategies. Clefts were classified into cleft lip and palate, cleft palate, isolated cleft of soft palate and submucous cleft. A modified Accordi s speech assessment protocol was utilized. Statistical analysis was performed using Pearson s correlation coefficient to evaluate associations and outcomes. Result: Eighteen patients (13 female, 5 male) out of twenty-two were consistent with therapy, aged 4 to 21years, mean age was 8.0 ± 4.4 S.D. Two (11%) fall into Class I, nine (50%) into Class II and seven (39%) into Class III. Most patients above the age of 10years have a class of II or III, there was mild correlation between the age of patients and the Class obtained (correlation coefficient=0.2). Conclusion: Speech therapy improves speech intelligibility in cleft patients after surgery. Better response observed in adult patients may be due to better understanding of placement and techniques.
  • Item
    Open Access
    Necrotizing fasciitis: A five years review of cases seen at the Lagos University Teaching Hospital
    (FDS, CMUL 2019, 2019-10-09) James, O.; Anorue, E.I.; Adamson, O.O.; Adeyemi, M.O.; Adekunle, A.A.; Ladeinde, A.L.; Ogunlewe, M.O.; Adeyemo, W.L.
    Background: Cranio-facial necrotizing (CFN) fasciitis of the head and neck is a bacterial infection characterized by spreading along fascia planes and subcutaneous tissue. This results in tissue necrosis and may lead to death. It is commonly triggered by odontogenic or pharyngeal infections. Aim: To retrospectively review cases seen in our center to determine the factors that might affect the outcome Patient and methods: This was a five years retrospective study of patients presenting with necrotizing fasciitis, treated at the Department of Oral and Maxillofacial Surgery, LUTH from 2014 to 2018. The medical records were reviewed for: aetiology, trigger factors and sites of infection, clinical manifestations, underlying medical condition, type of surgical treatment, medical and surgical complications, length of hospital stay and outcome of treatment. Results: Twenty –three patients with head and neck necrotizing fasciitis were treated during the study period. There were 11 males and 12 females in this group. The average age was 43 years, with age range between 22 and 84 years. Triger factor in most cases was odontogenic infection (18, 78.3%) while the upper part of the neck was the most prevalent site of presentation. Clinical presentations were a rapidly progressing painful neck swelling, fever, ulceration and trismus. Sixteen patients (69.5%) had no significant comorbidity. The other 7 patients (30.4%) had at least one significant comorbidity: diabetes (5 patients, (21.7%), malnutrition (2, 8.7%), alcoholism (2, 8.7%). All cases received early and aggressive medical treatment followed by serial surgical debridement. Sixteen cases were treated on outpatient bases. The duration of hospital stay for those admitted ranged from 4 to 34 days . Conclusion: Maintaining a high index of suspicion is crucially important for diagnosing CNF. Early diagnosis, timely resuscitation, and aggressive surgical debridement are the key to a successful clinical Necrotizing fasciitis requires early diagnosis and management to improve prognosis. Keywords: Necrotising, fasciitis, odontogenic, infection
  • Item
    Open Access
    Retrospective study of the clinicopathologic factors of recurrent Ameloblastoma of the jaws
    (2019-10-09) James, O.; Adamson, O.O.; Fashina, A.A.; Adeyemi, M.O.; Agbogidi, F.O.; Adekunle, A.A.; Adeyemo, W.L.; Ladeinde, A.L.; Ogunlewe, M.O.
    Background: Ameloblastomas are benign, locally aggressive, polymorphic neoplasms of proliferating odontogenic epithelial origin. Clinically, ameloblastoma appears as an aggressive odontogenic tumour, often asymptomatic and slow growing, with no evidence of swelling. Aim: To retrospectively review recurrent ameloblastomas cases during a 10-year period and to determine the recurrence rate of ameloblastoma and clinicopathologic factors involved in recurrence. Methodology: Records of clinicopathologically diagnosed and treated cases of recurrent ameloblastoma for a period of 10 years (2008 –2018) were obtained from the Department of Oral and Maxillofacial surgery, LUTH. Information derived include patients’ demographics, initial diagnosis, previous surgery done, year of recurrence, localisation of tumor and histologic diagnosis of recurrent tumor. Results: During the period of this study (2009-2018), 247 ameloblastoma cases were treated during the of which 32 (12%) were recurrent cases. 19 (59.4%) were females while 13 (40.6%) were males. Male to female ratio is 1:1.5. The ages ranges from 11- 60 with a mean of 37.03±12.57. Recurrence was more observed in the mandible 26 (81.3%) than the maxilla 4 (12.5%) and craniofacial region 2 (6.3%). The number of years for recurrence to occur ranges from 1-30 years with median of 4 years and interquartile range of 7.75. Most recurrence occurs between 3-5 years (40.6%) followed by 1-2 years (25%) of initial surgery. Conclusion: The recurrence rate after conservative treatment was higher than that after radical treatment. The choice of treatment should be adapted to the macroscopic and histological characteristics of each tumour.